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KMID : 0356820170330010007
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Korean Journal of Head & Neck Oncology
2017 Volume.33 No. 1 p.7 ~ p.13
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T Cell-directed Immunotherapeutic Approaches for Head and Neck Squamous Cell Carcinoma
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Choi Yoon-Seok
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Abstract
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Despite improved treatment outcomes of locally advanced disease over the last 2 decades, the survival of patients with recurrent and/or metastatic head and neck squamous cell carcinoma (HNSCC) remains dismal. There is a clear need for development of novel therapeutic strategies for recurrent and/or metastatic HNSCC. Recent advances in understanding tumor immunology have been directly and rapidly translated into clinical success of T cell-directed immunotherapeutic approach in the treatment of several types of solid cancers. Among them, impact of immune checkpoint inhibition using neutralizing antibodies is the most striking. A variety of immunotherapeutic strategies targeting T cells have been also studied in HNSCC, especially in recurrent and/or metastatic setting even with significant survival benefit. The present article reviews the basic concept of T cell-directed immunotherapy and the current status of such approaches in the treatment of HNSCC.
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KEYWORD
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head and neck cancer , T cell , immunotherapy , immune checkpoint inhibitor
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